Project 3 (Framingham): Identifying the cognitive and vascular effects of air pollution sources and mixtures in the Framingham Offspring and Third Generation Cohorts
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Short-term exposure to air pollution and digital vascular function.
We investigated associations between ambient air pollution and microvessel function measured by peripheral arterial tonometry between 2003 and 2008 in the Framingham Heart Study Offspring and Third Generation Cohorts. We measured particulate matter with aerodynamic diameter ≤2.5 µm (PM2.5), black carbon, sulfates, particle number, nitrogen oxides, and ozone by using fixed monitors, and we deter...
متن کاملResidential proximity to major roads, exposure to fine particulate matter and aortic calcium: the Framingham Heart Study, a cohort study
OBJECTIVES Traffic and ambient air pollution exposure are positively associated with cardiovascular disease, potentially through atherosclerosis promotion. Few studies have assessed associations of these exposures with thoracic aortic calcium Agatston score (TAC) or abdominal aortic calcium Agatston score (AAC), systemic atherosclerosis correlates. We assessed whether living close to a major ro...
متن کاملContributions of the Framingham Heart Study to stroke and dementia epidemiologic research at 60 years.
The Framingham Heart Study, the longest-running prospective epidemiologic study in history, was initiated in 1948 in response to the rising toll of coronary heart disease and hypertension. During the ensuing decades, the study of other diseases, notably stroke and dementia, was added. In 1971, 5124 offspring of the original cohort of 5209 men and women were added, and a third generation of 4095...
متن کاملThe Framingham Brain Donation Program: neuropathology along the cognitive continuum.
The Framingham Heart Study has enrolled 3 generations of participants, the original cohort (gen 1) enrolled in 1948, the offspring cohort (gen 2) enrolled in 1971 and the third generation enrolled in 2002. Participants have been undergoing prospective surveillance for incident stroke and dementia and embedded within this cohort is the voluntary Framingham Brain Donation Program that was begun i...
متن کاملParental occurrence of premature cardiovascular disease predicts increased coronary artery and abdominal aortic calcification in the Framingham Offspring and Third Generation cohorts.
BACKGROUND Parental premature cardiovascular disease (CVD) is a risk factor for coronary heart disease (CHD). We related validated parental premature CVD with the subclinical measures of coronary artery (CAC) and abdominal aortic (AAC) calcification in the community. METHODS AND RESULTS We studied 2 generations of Framingham Heart Study subjects who underwent multidetector computed tomography...
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تاریخ انتشار 2011